Table 2.
Risk-Reducing Oophorectomy (RRSO) and Ovarian Cancer (OC) Risk*
| No breast cancer prior** | Breast cancer prior*** | |||||
|---|---|---|---|---|---|---|
| Total | BRCA1 | BRCA2 | Total | BRCA1 | BRCA2 | |
| Total Participants | 1557 | 1003 | 554 | 1060 | 684 | 376 |
| RRSO (“Exposed”) | 465 | 342 | 123 | 474 | 339 | 135 |
| N (%) Post-RRSO Primary Peritoneal Cancer |
6 (2%) | 6 (2%) | 0 | 4 (1%) | 4 (1%) | 0 |
| No RRSO ( “Controls”) |
1092 | 661 | 431 | 586 | 345 | 241 |
| N (%) Controls with OC |
63 (6%) | 49(7%) | 14 (3%) | 35 (6%) | 27(8%) | 8 (3%) |
| Mean Age at RRSO (Yrs) |
43.2 (20.5-79.0) | 42.1 (20.5-79.0) | 46.2 (32.9-68.5) | 47.7 (29.7-75.2) | 44.1 (29.7-75.2) | 49.1 (30.4-72.9) |
| Mean Start Age (Yrs, for Controls) |
36.7 (18.1-90.4) | 35.4 (18.2-90.4) | 38.6 (32.9-68.5) | 45.4 (21.9-86.2) | 44.2 (21.9-86.2) | 47.0 (26.1-77.7) |
| Mean FU to OC (Yrs) |
6.2 (0.8-17.8) | 6.2 (0.8-17.8) | 6.0 (0.8-17.8) | 4.2 (0.5-13.4) | 4.4 (0.5-13.4) | 3.3 (0.7-5.8) |
| Mean Follow-up to Censoring (Yrs) |
5.7 (0.5-27.9) | 5.6 (0.5-27.7) | 5.8 (0.5-26.9) | 4.4 (0.5-24.6) | 4.5 (0.5-24.6) | 4.1 (0.5-15.4) |
| Occult Ov Ca^ | 9 | 7 | 2 | 13 | 10 | 3 |
| HR**** (95% CI);N | 0.28 (0.12-0.69); 1367 |
0.31 (0.12-0.82); 880 |
No cancer events; 487^^ |
0.14 (0.04-0.59); 857 |
0.15 (0.04-0.63); 563 |
No cancer events; 294 |
*
Participants censored at death, or last contact.
**
No breast cancer prior to RRSO, or in the controls prior to the start of follow up.
***
Breast cancer allowed prior to RRSO or start of follow up.
****
Adjusted for year of birth, oral contraceptive use; and stratified by center;
^
Found incidentally at the time of RRSO and excluded from analysis;
^^
Adjustment was made for OCP use; those with missing data were excluded from the analysis.