Table 3.
Risk-Reducing Oophorectomy (RRSO) and Breast Cancer (BC) Risk*
| No Prior Breast Cancer ** | Prior Breast Cancer *** | |||||
|---|---|---|---|---|---|---|
| Total | BRCA1 | BRCA2 | Total | BRCA1 | BRCA2 | |
| Total Participants | 1,370 | 869 | 501 | 647 | 397 | 250 |
| RRSO (“Exposed”) | 336 | 236 | 100 | 208 | 138 | 70 |
| N (%) Post-RRSO BC | 39 | 32 (14%) | 7 (7%) | 23 | 19 (14%) | 4 (6%) |
| No RRSO (“Controls”) | 1,034 | 633 | 401 | 439 | 259 | 180 |
| N (%) Controls with BC | 223 | 129 (20%) | 94 (23%) | 60 | 46 (18%) | 14 (8%) |
| Mean Age at RRSO (Yrs) | 43.8 (20.5- 79.0) |
42.7 (20.5- 79.0) |
46.6 (35.4- 68.5) |
48.5 (29.8- 74.8) |
48.2 (29.8- 74.8) |
49.1 (34.0- 69.5) |
| Mean Start Age (Yrs, for Controls) | 36.2 (18.1- 90.4) |
35.0 (18.2- 90.4) |
38.1 (18.1- 82.7) |
44.8 (21.9- 86.2) |
43.3 (21.9- 86.2) |
47.1 (27.1- 77.7) |
| Mean Follow-up to BC (Yrs) | 4.7 (0.5-21.0) | 4.7 (0.5-21.0) | 4.8 (0.5-20.6) | 4.4 (0.5-16.1) | 4.5 (0.5-16.1) | 4.0 (0.7-11.7) |
| Mean Follow-up to Censoring (Yrs) |
4.7 (0.5-27.8) | 4.7 (0.5-27.7) | 4.7 (0.5-27.8) | 3.8 (0.5-18.4) | 3.7 (0.5-18.4) | 3.9 (0.5-15.4) |
| HR**** (95% CI) | 0.54 (0.37- 0.79) |
0.63 (0.41- 0.96) |
0.36 (0.16- 0.82) |
1.00 (0.56- 1.77) |
1.01 (0.54- 1.89) |
1.11 (0.31- 3.98) |
*
Participants censored at OC, RRM, death, or last contact.
**
No breast cancer prior to RRSO, or in the controls prior to the start of follow up.
***
Breast cancer allowed prior to RRSO or start of follow up
****
Adjusted for year of birth and stratified by center.