Table 3.
Risk-Reducing Oophorectomy (RRSO) and Breast Cancer (BC) Risk*
No Prior Breast Cancer ** | Prior Breast Cancer *** | |||||
---|---|---|---|---|---|---|
Total | BRCA1 | BRCA2 | Total | BRCA1 | BRCA2 | |
Total Participants | 1,370 | 869 | 501 | 647 | 397 | 250 |
RRSO (“Exposed”) | 336 | 236 | 100 | 208 | 138 | 70 |
N (%) Post-RRSO BC | 39 | 32 (14%) | 7 (7%) | 23 | 19 (14%) | 4 (6%) |
No RRSO (“Controls”) | 1,034 | 633 | 401 | 439 | 259 | 180 |
N (%) Controls with BC | 223 | 129 (20%) | 94 (23%) | 60 | 46 (18%) | 14 (8%) |
Mean Age at RRSO (Yrs) | 43.8 (20.5- 79.0) |
42.7 (20.5- 79.0) |
46.6 (35.4- 68.5) |
48.5 (29.8- 74.8) |
48.2 (29.8- 74.8) |
49.1 (34.0- 69.5) |
Mean Start Age (Yrs, for Controls) | 36.2 (18.1- 90.4) |
35.0 (18.2- 90.4) |
38.1 (18.1- 82.7) |
44.8 (21.9- 86.2) |
43.3 (21.9- 86.2) |
47.1 (27.1- 77.7) |
Mean Follow-up to BC (Yrs) | 4.7 (0.5-21.0) | 4.7 (0.5-21.0) | 4.8 (0.5-20.6) | 4.4 (0.5-16.1) | 4.5 (0.5-16.1) | 4.0 (0.7-11.7) |
Mean Follow-up to Censoring (Yrs) |
4.7 (0.5-27.8) | 4.7 (0.5-27.7) | 4.7 (0.5-27.8) | 3.8 (0.5-18.4) | 3.7 (0.5-18.4) | 3.9 (0.5-15.4) |
HR**** (95% CI) | 0.54 (0.37- 0.79) |
0.63 (0.41- 0.96) |
0.36 (0.16- 0.82) |
1.00 (0.56- 1.77) |
1.01 (0.54- 1.89) |
1.11 (0.31- 3.98) |
Participants censored at OC, RRM, death, or last contact.
No breast cancer prior to RRSO, or in the controls prior to the start of follow up.
Breast cancer allowed prior to RRSO or start of follow up
Adjusted for year of birth and stratified by center.