Table 4b.
Risk-Reducing Oophorectomy (RRSO) and Breast Cancer-Specific Mortality*
| All eligible women | No breast cancer prior** | Breast cancer prior*** | |||||||
|---|---|---|---|---|---|---|---|---|---|
| All | BRCA1 | BRCA2 | All | BRCA1 | BRCA2 | All | BRCA1 | BRCA2 | |
| Total Participants |
2,407 | 1536 | 871 | 1,414 | 902 | 512 | 995 | 636 | 359 |
| RRSO ( “Exposed”) |
983 | 697 | 286 | 441 | 321 | 120 | 448 | 314 | 134 |
| N (%) Post- RRSO deaths |
21 (2%) | 16 (2%) | 5 (2%) | 2 (0.5%) | 2 (1%) | 0 | 16 (4%) | 11 (4%) | 5 (4%) |
| No RRSO ( “Controls”) |
1,424 | 839 | 585 | 973 | 581 | 392 | 547 | 322 | 225 |
| N (%) Controls deaths |
81 (6%) | 51 (6%) | 30 (5%) | 22 (2%) | 16 (3%) | 6 (2%) | 63 (12%) | 39 (12%) | 34 (11%) |
| Mean Age at RRSO (Yrs) |
45.3 (20.5- 75.2) |
44.4 (20.5-75.2) |
47.5 (30.4-72.9) |
43.2 (20.5-73.9) |
42.0 (20.5-73.9) |
46.4 (32.9-68.5) |
47.6 (29.7-75.2) |
47.0 (29.7-75.2) |
49.1 (30.4-72.9) |
| Mean Start Age (Yrs, for Controls) |
39.3 (18.1- 87.6) |
38.0 (18.2-87.6) |
41.2 (18.1-82.7) |
35.8 (18.1-87.6) |
34.5 (18.2-87.6) |
37.8 (18.1-82.7) |
45.1 (21.9-86.2) |
2.9 (0.6-10.2) |
4.7 (0.5-13.3) |
| Mean FU to death (Yrs) |
4.6 (0.5- 21.4) |
4.1 (0.6-21.4) |
5.4 (0.5-27.9) |
8.6 (1.6-21.4) |
8.5 (1.6-21.4) |
8.8 (2.8-18.3) |
3.6 (0.5-13.3) |
2.9 (0.6-10.2) |
4.7 (0.5-13.3) |
| Mean FU to Censoring (Yrs) |
5.0 (0.5-27.9) |
5.0 (0.5-27.7) |
4.9 (0.5-27.9) |
5.8 (0.5-27.9) |
5.7 (0.5-27.7) |
5.9 (0.5-27.9) |
4.5 (0.5-24.6) |
4.8 (0.5-24.6) |
4.1 (0.5-15.4) |
| HR**** (95% CI); |
0.44 (0.26- 0.76) |
0.38 (0.20-0.72) |
0.82 (0.30-2.20) |
0.27 (0.05- 1.33) |
0.30 (0.06- 1.53) |
No Deaths | 0.35 (0.19-0.67) |
0.27 (0.12-0.58) |
0.87 (0.32-2.37) |
*
Participants censored at the date of last contact.
**
No breast cancer prior to RRSO, or in the controls prior to the start of follow up.
***
Breast cancer allowed prior to RRSO or start of follow up.
****
Adjusted for year of birth and stratified by center;