TABLE 1.
DEMOGRAPHIC AND CLINICAL DATA FOR PATIENTS AND MATCHED CONTROL SUBJECTS
| All Patients (n = 72) |
Matched Volunteers (n = 21) |
P Value | |
|---|---|---|---|
| Mean age, years (range) | 58 (26–87) | 60 (24–84) | 0.89* |
| Percentage of patients male | 64 | 79 | 0.14† |
| Mean (95% CI) APACHE II score | 22 (20–23) | NA | |
| Median (IQR) days of ventilation before enrollment | 8 (6–10) | NA | |
| ICU mortality, % | 35 | NA | |
| Percentage with surgical diagnosis on admission | 52 | NA | |
| Percentage with ≥1 comorbidity | 54 | NA | |
| Percentage receiving immunosuppressant drugs (including corticosteroids) |
11 | 0 | |
| Median (IQR) serum C3a des-Arg, ng/ml | 606 (388–847) | 346 (216–400) | 0.0006‡ |
| Median (IQR) serum C5a des-Arg, ng/ml | 90 (59–141) | 36 (25–43) | <0.0001‡ |
| Median (IQR) serum GM-CSF, pg/ml | 3 (2–4) | 2 (0–5) | 0.34‡ |
| Median (IQR) BALF C3a, ng/ml | 15 (4–130) | 1 (0–1) | <0.0001‡ |
| Median (IQR) BALF C5a, ng/ml | 6 (0.5–30) | 1 (0–2) | 0.005‡ |
| Median (IQR) BALF GM-CSF, pg/ml | 2 (1–9) | 2 (0–4) | 0.23‡ |
| Median (IQR) BALF neutrophils, × 105/ml | 2.8 (0.4–16) | 0.03 (0.01–0.09) | <0.0001‡ |
| Median (IQR) BALF macrophages, × 105/ml | 1.8 (0.3–3.9) | 2.6 (1.9–6.24) | 0.04‡ |
Definition of abbreviations: APACHE II = Acute Physiology and Chronic Health Evaluation II; BALF = bronchoalveolar lavage fluid; CI = confidence interval; C3a/C5a des-Arg = breakdown products of complement factors C3a/C5a; GM-CSF = granulocyte-macrophage colony-stimulating factor; ICU = intensive care unit; IQR = interquartile range; NA = not applicable.
*
By t test.
†
By chi-square test.
‡
By Mann-Whitney U test.