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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: J Immunol. 2009 Jul 13;183(3):2122–2132. doi: 10.4049/jimmunol.0804187

Figure 9. Alpha defensins do not inhibit the exocytosis of TNF-α.

Figure 9

(a) HMDM were stimulated with CD40L/IFNγ (CI) either alone or in the presence of HNP1-3 (25ug/ml) for the indicated times. TNF-α protein released by HMDMs was measured by ELISA. (b) HMDMs were stimulated with LPS or CD40L/IFN-γ (CI) and treated with HNP1-3 (25ug/ml) or vehicle alone. At 4 hours post stimulation culture supernatants (i) were harvested prior to lysis of the HMDMs to reveal TNF-α retained within the cells (ii). *** p ≤0.001, error bars =SEM.