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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Oncogene. 2007 Sep 24;27(12):1805–1811. doi: 10.1038/sj.onc.1210805

FIGURE 2.

FIGURE 2

The RASSF2A promoter is frequently methylated in breast tumours.

Methylation status of the RASSF2A CpG island in primary breast tumours (T) was determined by MSP where M represents methylated-specific PCR and U represents unmethylated-specfic PCR. The MCF7 cell line was used as a positive control for the M PCR, CT represents water control. The RASSF2A CpG island promoter region was hypermethylated in 38 % (15/40) primary breast tumours. The corresponding normal DNA (N) was unmethylated suggesting that the methylation was tumour specific.