Table 2. Example Academic Drug Discovery Operations.
| Europe and rest of world |
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|
| Medical Research Council Technology – Centre for Therapeutics Discovery (MRC-CTD), London, UK |
| URL: http://www.mrctechnology.org/CO_DD.htm |
| Remit: To translate MRC-funded scientific discoveries into commercial products for healthcare benefit and to re-invest in future research |
| Focus: Wide target range across broad therapeutic areas |
|
|
| University of Dundee – Drug Discovery Unit (DDU), Dundee, UK |
| URL: http://www.drugdiscovery.dundee.ac.uk/ |
| Remit: Translational drug discovery for unmet medical needs and neglected diseases |
| Focus: Tropical diseases; novel targets and mechanisms; stem cells |
|
|
| Cancer Research Technology Discovery Laboratories (CRT), Cambridge & London, UK |
| URL: http://www.cancertechnology.com/pages/about_devlab_drugdisc.html |
| Remit: To translate CRUK-funded research into novel cancer therapies |
| Focus: Broad target approach to drug discovery and biotherapeutic development in cancer |
|
|
| Cancer Research UK Centre for Cancer Therapeutics (CRUK-CCT), London, UK |
| URL: http://www.icr.ac.uk/research/research_sections/cancer_therapeutics/index.shtml |
| Remit: To identify novel genes and pathways as targets and to implement novel technologies |
| Focus: HTS and HCS including phenotypic screening; target families including kinases, ATPases, protein:protein interactions, signalling pathways |
|
|
| University of Leuven – Centre for Drug Design and Discovery (CD3), Leuven, Belgium |
| URL: http://lrd.kuleuven.be/en/entrepreneur/collaboration/cd3/about.htm |
| Remit: To collaborate with academic research groups and small companies on innovative targets or approaches |
| Focus: Viral, bacterial, fungal diseases; CNS disorders; cancer |
|
|
| University of Liverpool, UK |
| URL: http://www.liv.ac.uk/science/industry/Drug_Discovery.html |
| Remit: medicinal chemsitry and pharmacology |
| Focus: Neglected tropical disease and drug safety |
|
|
| Northern Institute for Cancer research, Newcastle University , UK |
| URL: http://www.ncl.ac.uk/nicr/research/drug |
| Remit: medicinal chemistry and cancer cell biology |
| Focus: adult and paediatric cancer |
|
|
| University of British Columbia – Centre for Drug Research and Development (UBC-CDRD), Vancouver, Canada |
| URL: http://www.cdrd.ca/facilities-expertise/drug-screening |
| Remit: To advance promising discoveries to a commercially attractive stage and to build a collaborative research infrastructure |
| Focus: Cancer, CNS, diabetes, infectious diseases |
|
|
| Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Australia |
| URL: http://www.griffith.edu.au/science/eskitis-institute-cell-molecular-therapies |
| Remit: To investigate novel drug-and cell-based therapies for cancer, infection, neglected diseases, neurodegenerative diseases, stem cell biology |
| Focus: The “NatureBank” natural product resource; adult stem cell biology; breast cancer; Parkinson’s disease |
|
|
| Institut Pasteur Korea, Kwanggyo, South Korea |
| URL: http://www.ip-korea.org |
| Remit: To further the Institut Pasteur’s mission by applying Korean technology and competence in areas of neglected diseases |
| Focus: Infectious and chronic diseases; nanotechnology; PhenomicScreen™; high throughput flow cytometry |
|
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| USA |
|
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| Broad Institute, Cambridge, MA, USA |
| URL: http://www.broad.mit.edu/ |
| Remit: To capitalise on genome-related science and discoveries |
| Focus: Chemical Biology Platform encompassing chemistry, informatics and screening utilising HTS, HCS, phenotypic screens, RNAi screening |
|
|
| The Scripps Research Institute – Translational Research Institute, Florida, USA |
| URL: http://www.scripps.edu/florida/tri/ |
| Remit: Advanced Technologies and Drug Discovery components to the Translational Research Institute |
| Focus: Broad-based discovery structure including HTS, proteomics, flow cytometry, NMR, med chem., informatics |
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|
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St. Jude Children’s Research Hospital – Chemical Biology and Therapeutics Department HTS Core Facility, Memphis, TN, USA |
| URL: http://www.stjude.org/basicscience |
| Remit: To discover and develop novel chemical entities that increase understanding of the pathophysiology of or function as therapeutic leads for the treatment of catastrophic paediatric illnesses |
| Focus: Primarily childhood cancers |
|
|
| Southern Research Institute, Birmingham, AL, USA |
| URL: http://www.southernresearch.org |
| Remit: Drug Discovery Research Team focussing on cancer, infectious disease and neuroscience |
| Focus: HTS using BSL3 pathogens; antiviral, antimicrobial, anticancer screening |
|
|
| Drug Discovery Centre, University of Cincinnati, US |
| URL: http://www.drugdiscovery.uc.edu/capabilities/index.html |
| Remit: HTS, computational biology & chemistry, medicinal chemistry |
| Focus: development commercially viable entities from academic research, some focus on metabolic disease |
|
|
| Centre for Integrative Chemical Biology and Drug Discovery, UNC, US |
| URL: http://pharmacy.unc.edu/labs/center-for-integrative-chemical-biology-and-drug-discovery |
| Remit: HTS and medicinal chemistry aimed at development of leads and probe compounds to support target validation |
|
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| Small Molecule Discovery Center (SMDC) at University of California, San Francisco |
| URL: http://smdc.ucsf.edu/ |
| Remit: HTS and medicinal chemistry |
| Focus: Cancer and neglected infectious disease |
|
|
| Emory Institute for Drug Discovery, Atlanta, Georgia, US |
| URL: http://www.emory.edu/home/news/releases/2009/05/emory-institute-for-drug-discovery.html |
| Remit: medicinal chemistry, cellular biology, pharmacokinetic profiling and pharmacology and toxicology studies |
| Focus: Commercially neglected diseases –measles, malaria, tuberculosis |
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|
| Centre for Molecular Innovation and Drug Discovery, Northwestern University, Illinois, US |
| URL: http://www.cmidd.northwestern.edu/ |
| Remit: medicinal chemistry and biology to support translation of basic science |
|
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| Virginia Commonwealth University Insititute for Structural Biology and Drug Discovery |
| URL: http://www.vcu.edu/structuralbio/index.html |
| Remit: structural biology, medicinal chemistry and biophysics |
|
|
| University of Pittsburgh Chemical Diversity Centre and Drug Discovery Institute, PA, US |
| URLs: http://next.cancer.gov/discoveryResources/cbc_pitt.htm; http://www.upddi.pitt.edu |
| Remit: HTS, pharmacology and medicinal chemistry |
|
|
| University of Florida, Center for Drug Discovery |
| URL: http://www.cop.ufl.edu/centers/cdd/index.htm |
| Remit: Computational design, chemistry, PK and PD |
|
|
| Molecular Libraries Probe Production Centres (MLPCN), 10 locations across USA |
| URL: http://www.ncgc.nih.gov |
| Remit: HTS with follow-up chemistry |
| Focus: To provide a national resource in chemical probe development supporting target validation |