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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Cancer Res. 2010 Sep 21;70(19):7353–7359. doi: 10.1158/0008-5472.CAN-10-1012

Figure 1. The BRCA complex of HR repair and tumor suppression.

Figure 1

(A) The PALB2 gene locus in chromosome 16p12.2. The image is generated using the NCBI Sequence Viewer and slightly modified. (B) Schematic of the PALB2 protein structure showing its domains responsible for binding with BRCA1, BRCA2 and MRG15. (C) A proposed model of BRCA complex assembly at sites of DNA double strand breaks. It is currently unclear which BRCA1 BRCT domain binding partners (BRIP1/FANCJ, CCDC98-RAP80 or CtIP) exist in the core BRCA1/PALB2/BRCA2 complex. Also, BRCA1 may be recruited to damage sites via two distinct mechanisms- one by interacting with the MRE11/RAD50/NBS1 (MRN) complex and the other via its binding to the CCDC98/RAP80 complex, and it remains to be seen which branch is responsible for PALB2/BRCA2/RAD51 recruitment.