Figure 5. Effects of treatment with PS and/or BZ on primary MCL cells.

Normal CD34+ cells were treated with indicated doses of PS and BZ for 24 hours and the expression of GRP78, CHOP and NOXA was assessed by western blot analyses. The expression of β-actin served as the loading control. Alternatively, primary MCL cells were treated with the indicated doses of PS and/or BZ for 24 hours and the expression of GRP78, Erdj4, CHOP and β-actin was assessed by RT-PCR analysis. Data presented here are representative of two independent experiments.