Table 2. Selected proteins that are altered in ventral roots of G93A mice1.
| Accession# | Protein names | Spectral counts | p value2 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| C1 | C2 | A1 | A2 | C3 | C1 vs A1 | C2 vs A2 | A vs C3 | ||
| Proteins with increased level in G93A | |||||||||
| ER Stress | |||||||||
| NP_035162.1 | protein disulfide isomerase, prolyl 4-hydroxylase | 11 | 7 | 35 | 48 | 16 | 2.9E-04 | 4.7E-09 | 5.1E-04 |
| NP_031617.1 | calreticulin | 9 | 9 | 22 | 35 | 13 | 1.8E-02 | 5.1E-05 | 1.2E-02 |
| NP_031620.1 | calumenin isoform 1 | 3 | 1 | 10 | 13 | 1 | 4.6E-02 | 4.8E-04 | 9.3E-04 |
| Secretory pathway | |||||||||
| NP_034835.1 | galectin 3 | 0 | 1 | 20 | 18 | 2 | 1.5E-07 | 1.7E-05 | 6.7E-05 |
| NP_031496.2 | apolipoprotein D | 0 | 1 | 15 | 26 | 4 | 5.5E-06 | 7.7E-08 | 3.7E-04 |
| NP_033826.2 | apolipoprotein E | 5 | 5 | 47 | 71 | 7 | 3.9E-10 | 1.3E-16 | 7.7E-12 |
| Cellular structure | |||||||||
| NP_001106959.1 | septin 9 isoform b | 5 | 4 | 15 | 17 | 2 | 2.2E-02 | 3.2E-03 | 4.3E-04 |
| NP_780660.1 | cytoskeleton-associated protein 4 | 4 | 3 | 12 | 21 | 6 | 4.1E-02 | 9.7E-05 | 1.9E-02 |
| Metabolism | |||||||||
| NP_034551.2 | hexosaminidase A | 0 | 0 | 5 | 18 | 0 | 9.1E-03 | 6.4E-07 | 4.9E-05 |
| NP_034552.1 | hexosaminidase B | 0 | 0 | 14 | 36 | 0 | 1.1E-05 | 1.8E-12 | 4.3E-09 |
| Proteolysis | |||||||||
| NP_031824.1 | cathepsin B preproprotein | 0 | 0 | 5 | 14 | 0 | 9.1E-03 | 1.1E-05 | 2.1E-04 |
| NP_059068.1 | lysozyme 2 | 1 | 2 | 8 | 10 | 0 | 1.3E-02 | 1.6E-02 | 4.4E-04 |
| Proteins with decreased level in G93A | |||||||||
| NP_031736.1 | creatine kinase, muscle | 187 | 282 | 115 | 70 | 254 | 3.1E-05 | 1.3E-31 | 1.2E-18 |
| NP_058034.1 | myosin light chain | 3 | 28 | 0 | 0 | 6 | 4.4E-02 | 5.1E-10 | 4.2E-03 |
1
Results of two SOD1 G93A mutant mice (A1 and A2), two littermates (C1 and C2) and WT SOD1 overexpressing mice (C3)
The proteins detected in the spinal cord samples were further filtered by the same cutoff (p value < 0.05).
2
The p values were derived from G-test. In A vs C3 comparison, average spectral counts of A1 and A2 were used.