Table 1.

Shared clinic-pathologic features between BRCA-1 deficient and triple negative/Basal-like breast cancer. Figure adapted from 2009 ASCO Plenary Session(15).

Clinico-pathologic Characteristics	Hereditary BRCA1 Breast Cancer	Triple Negative/Basal-like Breast Cancer
ER/PR/HER2 status	Negative	Negative
TP53 status	Mutant	Mutant (Up to 80%)
BRCA1 status	Mutational Inactivation	Diminished Expression (?)
Gene-expression patterns	Basal-like	Basal-like
Tumor Histology	Poorly-differentiated (high grade)	Poorly-differentiated (high grade)
Chemosensivity to DNA-damaging chemotherapy	Highly sensitive	Likely sensitive
Genome-wide Aneuploidy	Yes	Yes