Table 3.

Concentrations of resveratrol and its major metabolites in normal tissue (proximal or distal to the tumor) and tumor tissue, obtained from the right (cecum, ascending colon, hepatic flexure) or left side (splenic flexure, descending colon, sigmoid colon, rectum) of the colorectum, in patients who received resveratrol daily for 8 days at 1.0g.

Species	Tissue Levels (nmol/g)*
	Proximal to Tumor		Tumor		Distal to Tumor
	Left	Right	Left	Right	Left	Right
Resveratrol	1.21±1.33 (0–5.23)	674±1303 (10.1–3774)	2.07±3.27 (0.30–8.68)	94.1±89.2 (12.7–195)	2.07±3.25 (0.28–9.40)	62.5±76.2 (10.7–272)
Resveratrol-3-O-glucuronide	0.19±0.22 (0–0.61)	10.8±17.2 (0–50.8)	lod**	0.75±0.70 (0–1.85)	0.28±0.29 (0–0.71)	0.83±0.81 (0–3.24)
Resveratrol-4′-O-glucuronide	0.43±0.41 (0–1.22)	1.71±1.87 (0–5.31)	0.38±0.47 (0–1.05)	0.53±0.79 (0–1.78)	0.53±0.48 (0–1.35)	0.83±0.77 (0–2.37)
Resveratrol sulfate glucuronide	19.5±4.82 (10.7–27.3)	27.1±21.6 (10.4–94.6)	20.7±5.04 (11.7–25.4)	29.1±12.8 (16.4–50.6)	25.2±17.2 (4.55–51.8)	18.4±5.76 (9.6–29.4)
Resveratrol-3-O-sulfate	0.67±0.56 (0–1.73)	67.2±119 (3.87–366)	0.16±0.39 (0–0.95)	10.4±13.6 (1.80–33.4)	1.10±1.21 (0–3.57)	5.82±3.02 (1.59–11.9)
Resveratrol-4′-O-sulfate	lod	3.43±3.36 (0.32–12.6)	lod	3.09±4.72 (0–11.33)	loq	0.90±0.70 (0–2.18)

^*Values are the mean±SD of 6 samples from tissues on the left side and 5 from the right side, with one tumor sample and between 1 and 3 normal tissue samples (proximal or distal to the tumor) per patient. Range in brackets.

^**lod=below the limit of detection; loq=close to or below the limit of quantitation.