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. Author manuscript; available in PMC: 2011 Aug 25.
Published in final edited form as: Cell Calcium. 2010 Aug 25;48(2-3):133–142. doi: 10.1016/j.ceca.2010.07.007

FIGURE 2.

FIGURE 2

Glucose-stimulated calcium (GSCa) and insulin (GSIS) responses following cytokine treatment. A, Representative traces of [Ca2+]i changes in response to glucose stimulation for islets treated with 0, 1/500, or 1/100 cytokine dose. B, Mean [Ca2+]i values at 3 and 28 mM glucose following different cytokine doses (n= number of islets for each treatment). C, Mean change in calcium following glucose stimulation (n= same as in B). D, Insulin secretion from 50 islets per condition during incubation in 3 mM glucose for 1 hour (white bars) followed by incubation in 28 mM glucose for 1 hour (black bars). E, Mean increase in insulin secretion following glucose stimulation. F, Mean increase in glucose stimulation index. * indicates P < 0.05 difference between insulin levels at 3 vs. 28 mM glucose for each cytokine dose. A total of 7 replicates for each condition were used for insulin measurements.