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Contributions of the endoplasmic reticulum and ion-channel activity to cytokine-induced changes in basal [Ca2+]i. A, Average of several traces from untreated (solid, n=9) and overnight cytokine-treated islets (dashed, n=8). Islets began in 3 mM glucose and were then treated with thapsigargin and then thapsigargin + nifedipine as shown. B, Mean change in [Ca2+]i during thapsigargin treatment and thapsigargin + nifedipine treatment. * indicates p<0.05.
