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. Author manuscript; available in PMC: 2011 Aug 25.

Published in final edited form as: Cell Calcium. 2010 Aug 25;48(2-3):133–142. doi: 10.1016/j.ceca.2010.07.007

TABLE 1.

Progressive islet dysfunction in db/db mice.

measurement	6 weeks		12 weeks
measurement	control	db/db	control	db/db
body weight (g)	21.1 ± 0.8 N = 12 mice	22.9 ± 1.1 N = 19 mice	27.7 ± 0.4 N = 6 mice	^*40.7 ± 1.2 N = 14 mice
blood glucose (mg/dl)	112.3 ± 5.4 N = 12 mice	123.5 ± 10.9 N = 19 mice	96.7 ± 10.5 N = 6 mice	^*344 ± 27.3 N = 14 mice
serum IL-1B (pg/ml)	14.2 ± 5.0 N = 6 mice	^*42.6 ± 15.1 N = 7 mice	2.8 ± 0.1 N = 4 mice	52.0 ± 17.1 N = 3 mice
basal calcium (3G)	0.815 ± 0.011 N = 25 islets	0.817 ± 0.012 N = 23 islets	0.776 ± 0.015 N = 14 islets	^*0.922 ± 0.022 N = 21 islets
peak calcium (28G)	1.122 ± 0.013 N = 25 islets	1.101± 0.010 N = 23 islets	1.339 ± 0.026 N = 14 islets	^*1.126 ± 0.023 N = 21 islets
GSCa	0.307 ± 0.019 N = 25 islets	0.284 ± 0.014 N = 23 islets	0.563 ± 0.038 N = 14 islets	^*0.204 ± 0.041 N = 21 islets
percent oscillating	92% (13 of 14)	^*42% (14 of 33)	92% (45 of 49)	^*17% (8 of 48)

^*

p < 0.05.

3G = 3 mM glucose, 28G = 28 mM glucose. Units for calcium measurements = fura-2 ratio (340/380 nm).