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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Cancer Res. 2010 Sep 28;70(19):7411–7420. doi: 10.1158/0008-5472.CAN-10-1438

Figure 4. AID-/- leukemia cells fail to downregulate p53.

Figure 4

A. Shown is the log2 expression ratio for the seven different p53 probe sets in the mouse genome 430 2.0 array for each of the AID+/+ samples (N=3) and AID-/- samples (N=3). B. Heat map of downstream p53 targets, molecules involved in the p53 stabilization and p53 degradation. C. Confirmatory quantitative RT-PCR of Ubqln2 and Cdkn1a mRNA levels in AID-/- mice (percentage of Hprt mRNA levels). For each gene, 5 AID-/- samples and 5 AID+/+ samples from different mice were analyzed. D. Western blot analysis of p53 protein levels. Protein from 6 AID-/- leukemia samples and 6 AID+/+ leukemia samples was extracted and evaluated for p53 expression. The AID-/- outlier by PCA component analysis is designated by an asterisk.