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Activation of NFAT activity by over expression of SH3BP2. RAW 264.7 cells were transiently transfected with wild-type or mutant SH3BP2 and incubated with sRANKL for 48 hours. All mutant SH3BP2 proteins produced significantly greater increases in NFAT luciferase activity compared to wild-type SH3BP2 (versus wild-type, R415Q p=0.02, P418R p=0.007, D419N p=0.002, and G420E p<0.0001). This figure represents data pooled from three independent experiments.
