Skip to main content
. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: J Orthop Res. 2010 Nov;28(11):1425–1430. doi: 10.1002/jor.21164

Figure 1b.

Figure 1b

TRAP activity is increased in the presence of SH3BP2. RAW 264.7 cells were transiently transfected with mutant (R415Q, G420E, P418R or D419N) or wild-type SH3BP2 and treated with sRANKL (100ng/ml). This figure demonstrates that in cells transiently transfected with mutant SH3BP2 cDNA there is significantly increased TRAP activity compared to the wild-type control (p<or=to 0.05). SH3BP2 levels, determined by immunoblot, show equivalent levels of the wild-type and mutant SH3BP2. This experiment was repeated three times with similar results.