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. 2010 Oct 8;87(4):465–479. doi: 10.1016/j.ajhg.2010.08.018

Figure 1.

Figure 1

Balanced Chromosome Translocation and FISH Mapping of the Chromosome 10 Breakpoint

(A) Ideogram and composite chromosomes illustrating the balanced t(10;12)(q26.12;q13.11)dn (revised in this paper from the original karyotypic assessment, t(10;12)(q26.3;q13.1)dn) in the KS patient.

(B) FISH mapping with BAC clone RP11-254K03, labeled with SpectrumGreen to metaphase spreads of the KS patient, resulted in hybridization to the normal chromosome 10, as well as the der(10) and der(12) chromosomes, indicating that the translocation breakpoint of chromosome 10 is located within the sequence of this BAC clone.