Table 2.

Twenty Most Strongly Associated SNPs from the Seoul Project for Log₁₀(Total Adiponectin) Based on Linear Regression Model

				Cohort 1 (n = 979)			Cohort 2 (n = 3,022)			Combined Set (n = 4,001)
Chromosome	SNP	Position	Nearest Gene	MAF	Effect (μg/ml)	p Value	MAF	Effect (μg/ml)	p Value	Effect (μg/ml)	p Value
16	rs3865188	81208218	CDH13	0.309	−0.095	1.685 × 10−15	0.296	−0.096	6.582 × 10−39	−0.096	7.793 × 10−51
16	rs12596316	81203653	CDH13	0.311	−0.088	4.763 × 10−13	0.298	−0.096	1.731 × 10−37	−0.094	8.287 × 10−47
16	rs7193788	81213661	CDH13	0.470	−0.057	3.643 × 10−07	0.449	−0.071	6.304 × 10−24	−0.068	2.484 × 10−28
16	rs3865186	81204473	CDH13	0.448	0.057	5.844 × 10−07	0.458	0.063	9.984 × 10−19	0.062	1.634 × 10−23
16	rs3852724	81203595	CDH13	0.448	0.057	6.225 × 10−07	0.458	0.063	6.727 × 10−19	0.062	1.046 × 10−23
16	rs3865185	81203963	CDH13	0.448	0.057	6.225 × 10−07	0.458	0.064	4.621 × 10−19	0.062	7.568 × 10−24
3	rs1438545	106535094	ALCAM	0.105	0.089	6.286 × 10−07	0.086	−0.014	0.2577	0.029	0.006585
1	rs12072620	188794697	FAM5C	0.177	−0.074	0.0000009	0.166	0.008	0.4387	−0.011	0.1741
1	rs1501501	188795068	FAM5C	0.177	−0.074	0.0000009	0.166	0.007	0.4664	−0.012	0.1629
13	rs4943398	36083064	LOC400120	0.217	−0.064	0.0000029	0.227	−0.020	0.02218	−0.032	0.00002418
11	rs4936310	110405970	C11orf53	0.229	0.066	0.0000043	0.182	0.018	0.04669	0.035	0.00001446
8	rs436753	88599977	CNBD1	0.318	0.063	0.0000063	0.268	−0.014	0.08527	0.006	0.3774
14	rs7148411	19629122	OR4K17	0.230	0.063	0.0000099	0.245	−0.008	0.3319	0.008	0.2529
12	rs17251474	91089449	BTG1	0.198	−0.064	0.0000114	0.195	0.008	0.3818	−0.010	0.1821
5	rs17156226	103533627	NUDT12	0.204	0.068	0.0000119	0.164	0.003	0.7811	0.026	0.002127
15	rs7171526	60497216	FLJ38723	0.118	−0.078	0.0000119	0.114	0.008	0.4576	−0.010	0.3096
8	rs10957333	66104003	CYP7B1	0.106	−0.080	0.0000163	0.106	−0.001	0.9349	−0.019	0.05887
1	rs2889921	220406261	KIAA1822L	0.167	−0.087	0.0000194	0.183	−0.018	0.05355	−0.036	0.00002391
4	rs11722604	157084201	CTSO	0.192	0.077	0.0000231	0.071	0.004	0.7631	0.052	0.000006402
10	rs2817677	98811818	SLIT1	0.229	−0.058	0.0000234	0.214	0.000	0.9617	−0.012	0.1117

Table lists the minor allele frequency (MAF), estimated effect size (β) for the 20 most significant SNPs identified from the Seoul cohort (cohort 1; n = 979), and their p values in a multiple linear regression model considering age, sex, smoking status, and body mass index under an additive model. MAF, estimated effect size (β), and p value for the Ansan cohort (cohort 2) are also shown.