Figure 6.

The target distribution of calretinin-positive interneurons is changed in the CA1 region of the epileptic human hippocampus. In controls, the calretinin-positive interneurons terminate on other interneuron dendrites (mainly on calretinin-positive and less frequently on unlabelled ones) and on principal cell dendrites. Ratio of calretinin-positive dendrites among the targets is decreased both in non-sclerotic and sclerotic samples. The ratio of terminals targeting unlabelled interneuron dendrites is increased in both groups. Ratio of pyramidal cell dendrites is decreased in non-sclerotic samples. In sclerotic cases pyramidal cell dendrites are not present among the targets. n = number of examined subjects; N  = number of examined calretinin-positive axon terminals.