TABLE 2.
Summary of Independent Mutations in the Testis cII Gene of Male Big Blue Mice Treated with AA or GA
| AAa |
GAa |
||||
| Control | 1.4mMb | 7.0mM | 1.4mMb | 7.0mMb | |
| Type of mutation | n (%) | n (%) | n (%) | n (%) | n (%) |
| G:C → A:T | 16 (53.3) | 15 (39.5) | 24 (42.9) | 17 (37.0) | 21 (30.4) |
| G:C → T:A | 6 (20.0) | 4 (10.5) | 8 (14.3) | 3 (6.5) | 8 (11.6) |
| G:C → C:G | 0 (0) | 6 (15.8) | 2 (3.6) | 4 (8.7) | 11 (15.9) |
| A:T → G:C | 0 (0) | 9 (23.7) | 5 (8.9) | 7 (15.2) | 7 (10.1) |
| A:T → C:G | 1 (3.3) | 0 (0) | 4 (7.1) | 4 (8.7) | 7 (10.1) |
| A:T → T:A | 1 (3.3) | 2 (5.3) | 6 (10.7) | 3 (6.5) | 7 (10.1) |
| Frameshift | 6 (20.0) | 2 (5.3) | 7 (12.5) | 8 (17.4) | 8 (11.6) |
| Total mutations | 30 | 38 | 56 | 46 | 69 |
a
There were no significant differences between low and high exposure concentrations of AA- or GA-treated groups.
b
The mutation spectra from AA-treated (1.4mM) and GA-treated (1.4 and 7.0mM) groups differed significantly from those of control group (p < 0.05).