Fig. 2.

Unadjusted (A) and multivariable-adjusted (B) log hazards (solid lines) and 95% CI (dashed lines) of all-cause mortality associated with time-varying levels of serum ALP in Cox models. Multivariable models were adjusted for age, race, comorbidities, blood pressure, BMI, smoking status, medication use, enrolment period, estimated GFR, serum albumin, bicarbonate, AST, ALT, calcium, phosphorus, blood haemoglobin, WBC, percentage of lymphocytes in WBC and 24-h urine protein. P-values represent the joint significance of the polynomial terms for ALP by the Wald test.