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. 2010 Apr 22;25(10):3348–3355. doi: 10.1093/ndt/gfq214

Table 2.

Minor allele frequency (MAF), Hardy–Weinberg equilibrium (HWE) and genotypic association for 34 SNPs genotyped in the klotho gene in 317 African American non-DM ESRD cases and 354 healthy African American controls

SNP Allele MAF
 HWE
 Genotypic association
r2 Controls Cases Controls Cases 2 DF Recessive OR CI
G-395A G/A 0.03 0.097 0.082 0.7545 1.0000 0.7021 0.8268 1.25 0.17–9.27
rs2772364 C/T 0.04 0.193 0.190 0.2272 1.0000 0.6916 0.6916 1.2 0.48–3.02
rs385564 G/C 0.03 0.259 0.268 0.2022 0.7711 0.7485 0.9643 0.99 0.55–1.77
rs526906 T/C 0.55 0.496 0.483 0.6629 0.8153 0.8443 0.5939 0.9 0.62–1.31
rs525014 T/C 0.19 0.347 0.337 0.0957 0.3662 0.1407 0.2160 1.37 0.83–2.24
rs571118 A/G 0.17 0.333 0.343 0.7187 0.5267 0.8571 0.9051 0.97 0.59–1.60
rs685417 G/A 0.18 0.392 0.372 0.5693 0.9014 0.6872 0.9718 0.99 0.63–1.55
rs9526992 G/A 0.09 0.234 0.209 0.2955 0.6037 0.3444 0.7799 1.11 0.53–2.32
rs2516571 A/G 0.13 0.224 0.247 0.4372 0.0834 0.0852 0.2483 0.65 0.31–1.35
rs2320762 T/G 0.02 0.291 0.294 0.6945 0.4787 0.8778 0.7405 0.91 0.50–1.63
rs9536282 C/T 0.08 0.295 0.277 0.3649 1.0000 0.6325 0.9769 1.01 0.56–1.83
rs520103 A/T 0.22 0.174 0.162 0.5712 0.2890 0.2824 0.1198 0.43 0.15–1.24
rs657049 A/G 0.20 0.458 0.422 0.5014 0.8113 0.3296 0.1368 0.74 0.49–1.10
rs9527023 T/C 0.99 0.180 0.168 0.7127 0.2985 0.8167 0.9073 1.05 0.45–2.43
rs9536314 T/G 1.00 0.187 0.168 0.7277 0.8411 0.7452 0.6000 0.79 0.33–1.89
rs9527025 G/C 0.29 0.184 0.166 1.0000 0.8378 0.7393 0.7309 0.86 0.35–2.07
rs2149860 A/G 0.00 0.439 0.408 0.8271 1.0000 0.4759 0.3644 0.83 0.55–1.25
rs522796 T/C 0.20 0.455 0.488 0.6626 0.1633 0.4754 0.2260 1.26 0.87–1.82
rs9527032a G/C 0.23 0.189 0.173 0.5966 1.0000 0.7487 0.4790 0.73 0.31–1.73
rs9596717a A/G 0.00 0.056 0.044 1.0000 1.0000 0.8250 - - -
T5266Aa T/A 0.00 0.014 0.008 1.0000 1.0000 - - - -
rs564481 C/T 0.00 0.088 0.104 0.0922 0.0029 0.8206 - - -
C365Ta C/T 0.01 0.007 0.003 1.0000 1.0000 - - - -
rs648202 C/T 0.12 0.393 0.440 0.4999 0.9069 0.2497 0.1108 1.4 0.93–2.13
rs649964 C/T 0.25 0.079 0.087 0.7083 0.4903 0.5785 0.2957 3.36 0.35–32.5
rs650439 A/T 0.02 0.257 0.292 0.5706 0.0172 0.0413 0.0135 2.07 1.16–3.69
C113Ta C/T 0.00 0.044 0.039 0.4998 1.0000 0.9412 - - -
rs11840531a T/C 1.00 0.045 0.029 0.1395 1.0000 0.4966 - - -
rs11840946a T/C 0.02 0.046 0.029 0.1478 1.0000 0.4359 - - -
rs643780a G/A 0.32 0.257 0.297 0.4839 0.0380 0.0450 0.0131 2.08 1.17–3.70
rs17643689a T/G 0.03 0.104 0.118 0.5594 0.0124 0.0953 0.0327 5.37 1.15–25.1
rs677332a A/G 0.17 0.175 0.161 0.5774 0.1354 0.2676 0.1160 0.4 0.13–1.26
rs582524a A/G 0.15 0.441 0.477 0.8252 0.1703 0.2461 0.0966 1.38 0.94–2.01
rs534184a G/T - 0.212 0.175 0.0762 1.0000 0.2540 0.1076 0.52 0.23–1.16

Genotypic association is shown after adjustment for African ancestry. Results from the two degrees of freedom test (2 DF) and recessive model are shown. Inter-SNP r2 is shown for the designated SNP and the SNPs immediately following.

OR, odds ratio; CI, confidence interval.

aSNPs that were identified in exon 4 and surrounding introns through sequencing.