Table 3.

Hardy–Weinberg equilibrium (HWE), minor allele frequency (MAF) and genotypic association (GA) for the most significant SNPs replicated in 557 African American non-DM ESRD cases and 187 healthy African American controls

SNP	Replicate non-DM ESRD cases (557) and controls (187)					Combined non-DM ESRD cases (874) and controls (541)
	MAF		HWE		GA	MAF		HWE		GA
	Controls	Cases	Controls	Cases	2 DF	Controls	Cases	Controls	Cases	2 DF
rs2516571	0.246	0.231	0.413	1.000	0.684	0.232	0.236	0.902	0.288	0.606
rs2149860	0.389	0.446	0.422	0.794	0.179	0.422	0.433	0.528	0.833	0.896
rs564481	0.049	0.059	1.000	0.245	2.000	0.076	0.076	0.103	0.081	0.843
rs648202	0.457	0.398	0.875	0.787	0.133	0.413	0.413	0.522	0.721	0.771
rs650439	0.253	0.259	1.000	0.739	0.946	0.255	0.271	0.565	0.224	0.376
rs643780	0.269	0.256	0.068	1.000	0.622	0.263	0.279	0.093	1.000	0.507
rs17643689	0.078	0.093	0.601	0.445	0.781	0.096	0.102	0.298	0.023	0.122
rs582524	0.380	0.387	0.122	0.000	0.759	0.422	0.423	0.308	0.047	0.863

We also analysed an association at these SNPs using the original and replicate non-diabetic ESRD cases (n = 874) and controls (n = 541) combined. Genotypic association is shown after adjustment for proportion of African ancestry.

2 DF, two degrees of freedom test.