Table 4.
Survival analysis to estimate risk of early age at onset of non-diabetic end stage renal disease in 317 non-DM ESRD cases and 354 healthy controls
| SNP | Alleles | Dominant model |
Recessive model |
Additive model |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| P-value | HR | CI | P-value | HR | CI | P-value | HR | CI | ||
| G-395T | G/A | 0.968 | 0.99 | 0.820 | 1.18 | 0.993 | 1.00 | |||
| rs2772364 | C/T | 0.100 | 0.81 | 0.632 | 1.18 | 0.185 | 0.86 | |||
| rs385564 | G/C | 0.166 | 1.18 | 0.633 | 1.11 | 0.194 | 1.13 | |||
| rs526906 | T/C | 0.004 | 1.51 | (1.14, 1.99) | 0.152 | 1.24 | 0.006 | 1.27 | (1.07, 1.51) | |
| rs525014 | T/C | 0.021 | 1.33 | (1.04, 1.69) | 0.124 | 1.34 | 0.014 | 1.25 | (1.05, 1.49) | |
| rs571118 | A/G | 0.004 | 1.41 | (1.11, 1.79) | 0.413 | 1.18 | 0.010 | 1.26 | (1.06, 1.51) | |
| rs685417 | G/A | 0.078 | 1.24 | 0.214 | 1.25 | 0.057 | 1.18 | |||
| rs9526992 | G/A | 0.274 | 0.87 | 0.597 | 1.15 | 0.464 | 0.93 | |||
| rs2516571 | A/G | 0.582 | 0.93 | 0.204 | 0.66 | 0.347 | 0.91 | |||
| rs2320762 | T/G | 0.062 | 1.26 | 0.454 | 1.20 | 0.067 | 1.20 | |||
| rs9536282 | C/T | 0.118 | 0.83 | 0.274 | 0.78 | 0.092 | 0.85 | |||
| rs520103 | A/T | 0.866 | 0.98 | 0.069 | 0.35 | 0.451 | 0.92 | |||
| rs657049 | A/G | 0.697 | 0.95 | 0.189 | 0.81 | 0.314 | 0.92 | |||
| rs9527023 | T/C | 0.929 | 1.01 | 0.272 | 1.41 | 0.671 | 1.05 | |||
| rs9536314 | T/G | 0.979 | 1.00 | 0.401 | 1.33 | 0.824 | 1.03 | |||
| rs9527025 | G/C | 0.839 | 0.97 | 0.294 | 1.43 | 0.907 | 1.01 | |||
| rs2149860 | A/G | 0.649 | 1.06 | 0.347 | 1.17 | 0.418 | 1.07 | |||
| rs522796 | T/C | 0.300 | 1.15 | 0.034 | 1.35 | (1.02, 1.77) | 0.061 | 1.17 | ||
| rs648202 | G/C | 0.966 | 1.01 | 0.385 | 1.34 | 0.771 | 1.03 | |||
| rs649964 | A/G | 0.756 | 1.07 | 0.969 | 0.00 | 0.812 | 1.05 | |||
| rs650439 | T/A | 0.182 | 0.55 | . | . | 0.182 | 0.55 | |||
| rs9527032 | C/T | 0.142 | 1.26 | 0.011 | 2.62 | (1.24, 5.53) | 0.043 | 1.32 | (1, 1.72) | |
| rs9596717 | C/T | 0.372 | 0.53 | . | . | 0.372 | 0.53 | |||
| T5266A | C/T | 0.584 | 0.93 | 0.198 | 1.21 | 0.727 | 1.03 | |||
| rs564481 | C/T | 0.738 | 0.95 | 0.036 | 3.40 | (1.08, 10.69) | 0.991 | 1.00 | ||
| C365T | A/T | 0.997 | 1.00 | 0.103 | 1.36 | 0.476 | 1.07 | |||
| C113T | C/T | 0.918 | 0.98 | 0.980 | 0.00 | 0.896 | 0.97 | |||
| rs11840531 | T/C | 0.224 | 0.73 | 0.972 | 0.00 | 0.192 | 0.72 | |||
| rs11840946 | T/C | 0.199 | 0.72 | 0.972 | 0.00 | 0.171 | 0.71 | |||
| rs643780 | G/A | 0.667 | 1.05 | 0.076 | 1.40 | 0.270 | 1.11 | |||
| rs17643689 | T/G | 0.568 | 1.09 | 0.019 | 2.48 | (1.16, 5.28) | 0.268 | 1.16 | ||
| rs677332 | A/G | 0.873 | 1.02 | 0.239 | 0.43 | 0.875 | 0.98 | |||
| rs582524 | A/G | 0.823 | 1.03 | 0.020 | 1.38 | (1.05, 1.8) | 0.139 | 1.13 | ||
| rs534184 | G/T | 0.976 | 1.00 | 0.665 | 0.85 | 0.874 | 0.98 | |||
P-values and hazard ratios (HR) are reported for the dominant, additive and recessive models both before and after adjustment for sex, BMI and African ancestry. Confidence intervals (CI) are reported for significant P-values. Alleles are shown with the major allele, followed by the minor allele (the minor allele was the reference allele for the association tests).