Table 3.
Multivariable relative risk (RR) of pregnancy among 5-year survivors of Ewing sarcoma and siblings of childhood cancer survivors*
| Variable | Men | Women | ||
| RR (95% CI) | P | RR (95% CI) | P | |
| Siblings | 1.00 (referent) | 1.00 (referent) | ||
| Survivors | 0.38 (0.24 to 0.59) | <.001 | 0.65 (0.48 to 0.88) | .005 |
| Marital status | ||||
| Never married | 1.00 (referent) | 1.00 (referent) | ||
| Currently married | 7.07 (4.85 to 10.31) | <.001 | 6.21 (4.55 to 8.46) | <.001 |
| Formerly married | 4.48 (2.87 to 6.99) | <.001 | 4.41 (2.76 to 7.05) | <.001 |
| Race/ethnicity | ||||
| White, non-Hispanic | 1.00 (referent) | 1.00 (referent) | ||
| Black, non-Hispanic | 2.53 (1.30 to 4.91) | .006 | 1.31 (0.71 to 2.44) | .38 |
| Hispanic | 2.11 (1.09 to 4.09) | .027 | 1.08 (0.61 to 1.91) | .78 |
| Other | 1.75 (1.06 to 2.90) | .03 | 1.29 (0.87 to 1.92) | .21 |
| Educational attainment | ||||
| No high school/GED | 1.00 (referent) | 1.00 (referent) | ||
| High school/GED | 0.80 (0.48 to 1.34) | .4 | 0.97 (0.60 to 1.55) | .89 |
| Some college | 0.48 (0.29 to 0.79) | .004 | 0.67 (0.43 to 1.06) | .089 |
| Bachelor’s or higher | 0.39 (0.23 to 0.65) | <.001 | 0.38 (0.24 to 0.59) | <.001 |
| Smoking status | ||||
| Never smoked | 1.00 (referent) | 1.00 (referent) | ||
| Current smoker | 0.78 (0.59 to 1.04) | .097 | 0.84 (0.63 to 1.11) | .22 |
| Former smoker | 0.71 (0.55 to 0.91) | .008 | 0.68 (0.54 to 0.86) | .002 |
| Age at cancer diagnosis, y | ||||
| 0–4 | 1.99 (1.43 to 2.76) | <.001 | 1.83 (1.36 to 2.45) | <.001 |
| 5–9 | 1.05 (0.80 to 1.38) | .72 | 1.64 (1.29 to 2.08) | <.001 |
| 10–14 | 0.84 (0.66 to 1.07) | .16 | 1.31 (1.05 to 1.64) | .018 |
| 15–20 | 1.00 (referent) | 1.00 (referent) | ||
*
Both RR and confidence interval (CI) were estimated from Cox proportional hazards parameters. Two-sided P values were based on likelihood ratio tests. GED = general education development (high school equivalency).