TABLE 2.
Expected Clinical Manifestations in Target Tissue Hypersensitivity or Resistance to Glucocorticoids *
| Target area | Glucocorticoid excess = Glucocorticoid hypersensitivity | Glucocorticoid deficiency = Glucocorticoid resistance |
|---|---|---|
| Central nervous system | Insomnia, anxiety, depression, defective cognition | Fatigue, somnolence, malaise, defective cognition |
| Liver | + Gluconeogenesis, + lipogenesis | Hypoglycemia, resistance to diabetes mellitus |
| Fat | Accumulation of visceral fat (metabolic syndrome) | Loss of weight, resistance to weight gain |
| Blood vessels | Hypertension | Hypotension |
| Bone | Stunted growth, osteoporosis | |
| Inflammation/immunity | Immune suppression, anti-inflammation, vulnerability to certain infections and tumors |
+ Inflammation, + autoimmunity, + allergy |