. Author manuscript; available in PMC: 2010 Oct 4.

Published in final edited form as: Org Lett. 2008 Jul 12;10(16):3505–3508. doi: 10.1021/ol801285g

Table 2.

Coupling of Electron-Deficient Anilines



entry^a	ArCI	aniline	product	yield^b
1				94%
2				86%^c
3				86%
4				93%
5				95%
6				92%^d

^[a]

Reaction conditions: 1 min preactivation at 110 °C with 4 mol % H₂0, 1 mol % Pd(OAc)₂, and 3 mol % 1 in 2 mL/mmol of t-BuOH; 1.0 equiv aryl chloride, 1.2 equiv amine, and 1.4 equiv K₂CO₃.

^[b]

Yields represent isolated yields (average of 2 runs).

^[c]

Reaction time of 2 h.

^[d]

2.5 equiv of K₂CO₃ was used.