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. 2010 Sep;17(9):444–453. doi: 10.1101/lm.1757410

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Figure 2. — Cocaine-induced CPP is disrupted in a reactivation-dependent manner following intra-AcbC zif268 ASO prior to memory reactivation. Time spent on the cocaine- (black bars) and saline-paired (white bars) sides are shown for the reactivated (C–E; MSO = 10, ASO = 7) and nonreactivated (F,G; MSO = 12, ASO = 11) groups. The timeline of the experimental procedures for the reactivated and nonreactivated memory conditions are shown in A and B, respectively. (C) There was no difference between the groups during the preconditioning test. (D) Both groups acquired a significant preference for the cocaine-paired side as assessed in the memory-reactivation test. (E) The ASO group had a significantly impaired preference for the cocaine-paired side during the post-reactivation test. (F) The nonreactivated groups also did not differ during the preconditioning test. (G) Both groups showed a significant preference for the cocaine-paired side during the post-treatment preference test. Data are presented as mean ± SEM.