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. 2010 Sep 26;2010:598109. doi: 10.1155/2010/598109

Figure 1.

Figure 1

Signal transduction pathways during the priming phase of liver regeneration. Interactions between Kupffer cells and hepatocytes are also illustrated while other nonparenchymal cells are also possibly involved. AP-1, activator protein; C3aR, activated compliment 3 receptor; C5aR, activated compliment 5 receptor; Gadd45β, growth arrest and DNA-damage-inducible gene 45β ; IKK, inhibitor of nuclear factor κB kinase; IL-6, interleukin-6; JAK, Janus-associated kinase; JNK, c-jun N-terminal kinase; MKK7, mitogen-activated protein kinase 7; MyD88, myeloid differentiation factor 88; NEMO, nuclear factor κB essential modulator; RIP, receptor interacting protein; TLR, toll-like receptor; TNFα, tumor necrosis factor α; TRIF, TIR-domain containing adaptor inducing interferon-β.