. 2010 Sep 27;2010:282896. doi: 10.1155/2010/282896

Table 4.

Serum PFNA concentrations at weaning in PPARα-KO and WT Adult female mice and offspring exposed to PFNA on GD 1–18.

Strain	Dose (mg/kg/day)	Adult females with no live pups		Adult females with live pups		Pups (sexes combined)
Strain	Dose (mg/kg/day)	n	PFNA (μg/ml)	n	PFNA (μg/ml)	n litters	PFNA (μg/ml)
	0	14	0.067 ± 0.005	12	0.022 ± 0.004	9	0.033 ± 0.008
	0.83	13	28.5 ± 1.22^a	10	8.91 ± 1.51^a	8	9.60 ± 9.37^a
WT	1.1	26	39.7 ± 1.26^a	10	23.2 ± 2.57^a	5	15.7 ± 1.42^a
	1.5	23	48.4 ± 1.54^a	13	21.0 ± 3.01^a	10	17.5 ± 1.15^a
	2.0	26	64.0 ± 2.46^a	11	35.3 ± 3.90^a	7	25.3 ± 2.70^a

	0	9	0.048 ± 0.008	16	0.016 ± 0.001	16	0.068 ± 0.027
	0.83	8	38.4 ± 2.34^a	11	2.76 ± 0.172^a	12	15.2 ± 1.01^a
KO	1.1	11	53.9 ± 2.51^a	13	4.17 ± 0.310^a	12	19.4 ± 0.69^a
	1.5	37	72.1 ± 2.91^a	8	11.8 ± 5.71^a	7	26.4 ± 1.39^a
	2.0	23	83.4 ± 2.93^a	15	22.6 ± 5.69^a	12	38.4 ± 1.80^a

Values are means ± SEM or litter means ± SEM. Serum was collected from all adult females and from 2 pups per litter at 23 days post dose.

WT: wild type; KO: PPARα knockout.

^a Significantly different from control values by P < .0001. See text for more statistical comparisons.