Figure 3.

Uptake of different liposomes encapsulating mitoxantrone in various cell lines by confocal laser scanning fluorescence microscopy. Various cell lines were treated with either LHRH-MTX-SL or MTX-SL for four hours at 37°C. A LHRH-MTX-SL in LHRH receptor high-expressing MCF-7 cells; B MTX-SL in LHRH receptor high-expressing MCF-7 cells; C MCF-7 cells treated with drug-free medium used as a control; D LHRH-MTX-SL in LHRH receptor low-expressing SK-OV-3 cells; E MTX-SL in LHRH receptor low-expressing SK-OV-3 cells; F SK-OV-3 cells treated with drug-free medium used as a control.

Abbreviations: LHRH, luteinizing hormone-releasing hormone; MTX, mitoxanthrone; SL, loaded liposomes.