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Analysis of the donepezil effect on the dendritic spine density. The density of the dendritic spines increased in the 12 months old rats with donepezil compared to their corresponding age group (** = P < 0.05, CA1 dorsal hippocampus; * = P < 0.01, rest of the regions) in all the regions studied. At 20 months old, the number of dendritic spine from neurons of the dorsal hippocampus and prefrontal cortex showed a trend to increase after donepezil treatment. (& = P = 0.07).
