Figure 5. Glycemic control of NOD.scid mice transplanted with human islet preparations with varying islet quality scores.
Streptozotocin-induced diabetic NOD.scid mice were transplanted under the kidney capsule with 1000 or 2000 IEQ doses of human islet preparations with Islet Quality Scores (IQS) <0 (left panels) or >0 (right panels). Mice were considered cured if blood glucose levels fell below < 200 mg/dL within 14 days of transplant and were maintained at or below that level until return to the hyperglycemic state following nephrectomy of the graft bearing kidney.