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. Author manuscript; available in PMC: 2011 Sep 1.
Published in final edited form as: J Psychiatr Res. 2010 Feb 20;44(12):788–794. doi: 10.1016/j.jpsychires.2010.01.013

Table 1.

Association of estrogen receptor alpha (ESR-1) SNPs with psychological traits

SNP Neuroticism Extraversion Impression
Management		 Emotional
Stability		 Harm
Avoidance		 Abstractedness Apprehension
L0017
L0018
L0019
L0020
L0024
L0055 F=6.8*
L0058 F=4.0* F=4.4* F=9.0**
L0025† F=4.0*
L0060† F=5.3* F=6.7**
L0061† F=7.3** F=6.5*
L0057
L0026† F=4.1* F=6.8* F=5.7*
L0056
L0021
L0023
L0022

Bold SNPs are from intron 4 of ESR-1

†

SNPs significantly associated with PMDD.

*

Genotypic effects significant at p<0.05

**

Genotypic effects significant at p<0.01

Eleven out of twelve of the significant associations between ESR-1 SNPs and personality traits distinguishing PMDD patients from controls were found in intron 4 of the ESR-1.