Proposed model of the miR159-GAMYB regulatory pathway in Arabidopsis. GAMYB-like proteins are present in the aleurone, indicating low activity of miR159. In this tissue, we hypothesize that they transduce the GA signal for the activation of GA-induced genes, which leads to nutrient secretion and the progression of PCD. Conversely, strong miR159 activity fully represses MYB33 and MYB65 in vegetative tissues, ensuring that aleurone-related genes remain inactive to allow the progression of growth. GA appears not associated with the miR159-GAMYB regulatory module in these tissues.