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Conformational flexibility of the J-K loop of EphA4. The superimposed structures are the two chains reported here (green and cyan) and three structures of ligand-bound EphA4 - 2WO2 (yellow), 3GXU (pink) and 2WO3 (magenta). A helical region is found in the J-K loop of EphA4 bound to an A class ephrin, but also in one of the structures of unbound EphA4 (chain A of our structure).
