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. Author manuscript; available in PMC: 2010 Oct 4.
Published in final edited form as: Pharmacogenomics J. 2009 Jan 27;9(2):127–136. doi: 10.1038/tpj.2008.19

Table 3.

Kinetic parameters of paraquat and metformin in cells expressing hMATE1 reference and polymorphic variants.

Vmax (pmol/mg/min) Km (μM) Vmax/Km Ratio (pmol/mg/min/μM)
Paraquat
 hMATE1-reference 257 ± 16 169 ± 44 1.58 ± 0.32
 hMATE1-L125F 292 ± 111 196 ± 65 1.50 ± 0.40
  P value 0.620 0.587 0.804
Metformin
 hMATE1-reference 705 ± 210 227 ± 42 3.07 ± 0.35
 hMATE1-L125F 552 ± 108 286 ± 27 1.91 ± 0.20
 hMATE1-V338I 629 ± 100 264 ± 66 2.40 ± 0.21
  P value 0.635 0.526 0.051

Note: For paraquat, unpaired Student’s t-test was used to analyse differences between hMATE1 reference and hMATE1-L125F. For metformin, one-way analysis of variance was used to analyse differences among hMATE1 reference, hMATE1-L125F and hMATE1-V338I.