. Author manuscript; available in PMC: 2011 Sep 1.

Published in final edited form as: J Clin Immunol. 2010 Jul 16;30(5):703–722. doi: 10.1007/s10875-010-9441-2

Table III.

Peptides that Induce Responses in CD8+ T Cells of HSV-2 Seropositive Subjects

ORF	Peptide^c	Location in ORF	Subject	HLA-A and -B types^b	Epitope IC50 (μM)^d
UL19	AFEDRSYPAVFYLLQ	617–633	Pt 04	A01, A03, B08, B63	358
UL25	HNLFLWEDQTLLRAT	369–383	Pt 11	A02, A11, B08, B15	2–32
	“	“	Pt 02	A02, A34, B35, B62
	“	“	Pt 09	A01, A02, B08, B44
	“	“	Pt 10	A02, A24, B35, B44
	“	“	Pt 07	A02, A03, B07, B44
	DRLDNRLQLGMLIPG	405–419	Pt 12	A02, A32, B14, B44	79–102
UL46	RLGPADRRFVALSGS	249–263	Pt 13	A03, B07, B47	112
	“	“	Pt 01	A03, B07
	“	“	Pt 08	A01, A03, B07, B08
	AQREAAGVYDAVRTW	533–547	Pt 14	A03, A68, B35, B53	7 (EV9)
	“	“	Pt 03^a	A01, B57	216 (GW9)
UL49	PMRARPRGEVRFLHY	45–59	Pt 01	A03, B07	23
	“	“	Pt 15	A02, A30, B07, B35
	“	“	Pt 16^a	A01, A31, B07, B60
	“	“	Pt 17^a	A02, A74, B07, B14
	“	“	Pt 08^a	A01, A03, B07, B08
	“	“	Pt 05	A24, A31, B07, B62
	ARPRRSASVAGSHGPG	81–96	Pt 01	A03, B07	7
	“	“	Pt 18	A02, A68, B07, B14
	HGPGPARAPPPPGGPV	93–108	Pt 01	A03, B07	47
	PKASATPATDPARGR	129–143	Pt 01	A03, B07	170
	KNLLQRANELVNPDA	249–263	Pt 08	A01, A03, B07, B08	35
ICP0	EAGLMDAATPPARPPA	77–92	Pt 19	A24, A30, B18, B40	54
	LHPFCIPCMKTWIPL	145–159	Pt 20	A01, A03, B07, B08	119
	DFIWTGNPRTAPRSL	209–223	Pt 13^a	A03, B07, B47	5
	“	“	Pt 07	A02, A03, B07, B44
	LPIAGVSSVVALAPY	689–703	Pt 21	A33, A74, B18, B35	169
	“	“	Pt 10	A02, A24, B35, B44
	DMETGHIGAYVVLVD	717–731	Pt 06^a	A03, A11, B39, B51	B39 allele not in IEDB
	GHIGAYVVLVDQTGN	721–735	Pt 22	A29, A68, B71, B37	250. B37/71 not in IEDB
	RAAAPAWSRRTLLPE	741–755	Pt 01	A03, B07	7
	“	“	Pt 07	A02, A03, B07, B44
	“	“	Pt 05	A24, A31, B07, B62
	PVGNMLFDQGTLVGA	779–793	Pt 23^a	A02, B50, B62	2–36
UL39	LMLEYFCRCAREESK	346–359	Pt 24	A03, A11, B07, B51	710
	GVLVHLRIRTREASF	433–447	Pt 25^a	A02, A03, B49, B62	94
	“	“	Pt 04	A01, A03, B08, B63	32
	FGGHYMESVFQMYTR	515–529	Pt 03	A01, B57	183
	SMSLADFHGEEFEKL	725–739	Pt 08^a	A01, A03, B07, B08	184
	KTSNALCVRGARPFS	911–925	Pt 16	A01, A31, B07, B60	17
UL29	CPLLIFDRTRKFVLA	1,013–1,027	Pt 26^a	A24, A34, B14, B50	Alleles not in IEDB

Responses to the adjacent downstream 15-mer were also detected,

HLA types in bold text represent those most likely restricting the

epitope response, predicted by commonly shared types, supertype motif conservation and/or

lowest IC50 (smm method) scores using HLA binding prediction programs at IEDB