Table 3.
Physiological ramifications of RAS miRSNPs.
| RAS Component | Loss of Function miRSNP | Physiological Result | Gain of Function miRSNP | Physiological Result |
|---|---|---|---|---|
| AGTR1 (AT1R) | AT1R↑ | Hypertension Cardiac/vascular remodeling Atherosclerosis | AT1R↓ | Antihypertensive Antiremodeling Anti-atherosclerosis |
| ACE | ACE↑ | ACE↓ | ||
| AGT | AGT↑ | AGT↓ | ||
| REN | REN↑ | REN↓ | ||
| ATP6AP2 (PRR) | PRR↑ | PRR↓ | ||
| AGTR2 (AT2R) | AT2R↑ | Antihypertensive Antiremodeling Antiatherosclerosis | AT2R↓ | Hypertension Cardiac/vascular remodeling Atherosclerosis |
| ACE2 | ACE2↑ | ACE2↓ | ||
| MAS1 (MasR) | MasR↑ | MasR↓ | ||
| LNPEP (AT4R) | AT4R↑ | AT4R↓ |