Table 1. Number of miRNAs that changed in brain and blood 24 h after each experimental condition as compared to untouched controls (C).

Comparison	Up- or downregulated	Sample	No. of miRNA detectable	miRNAs regulated in both brain and blood (fold change >1.5)	No. of regulated miRNA
					Fold change >1.5	Fold change >1.5 and P<0.05	Fold change >1.5, P<0.05 and FDR <0.05
SI versus C	Up	Brain	198	miR-298, miR-503, miR-672	43	5	0
		Blood	49		19	3	0
	Down	Brain	85	miR-155,a miR-362-3p	26	1	0
		Blood	103		44	1	0
I versus C	Up	Brain	168	miR-10a, miR-182, miR-200b, miR-298	43	6	1
		Blood	33		16	3	1
	Down	Brain	115	miR-155,a miR-362-3p,a miR-223, miR-210	22	5	2
		Blood	119		92	38	19
SH versus C	Up	Brain	143	miR-148b, miR-503	36	3	0
		Blood	76		19	3	0
	Down	Brain	140	miR-10b,a miR-203, miR-362-3p	27	8	4
		Blood	76		36	3	2
B versus C	Up	Brain	163	miR-298,a miR-200b,a miR-205,a miR-345, miR-423-5p	34	6	0
		Blood	104		39	4	1
	Down	Brain	120	None	31	7	2
		Blood	48		20	1	0
LB versus C	Up	Brain	150	miR-298,a miR-423-5p,a miR-10a, miR-345-5p, miR-674	34	6	0
		Blood	87		30	6	1
	Down	Brain	133	miR-155, miR-20b-3p, miR-200a	28	6	1
		Blood	65		33	6	0
T versus C	Up	Brain	234	miR-107,a miR-200b, miR-331-5p, miR-672	69	12	0
		Blood	29		17	2	0
	Down	Brain	49	miR-155,a miR-188-5pa	19	3	3
		Blood	123		63	10	0
K versus C	Up	Brain	104	miR-298a	21	1	0
		Blood	47		15	2	0
	Down	Brain	179	miR-155,a miR-29c, miR-34b-3p, miR-98, miR-122, miR-203, miR-450a	39	9	4
		Blood	105		43	1	0

miRNA, microRNA; RT-PCR, real-time PCR.

Experimental conditions included untouched control (C), sham ischemia (SI), ischemia (I), sham hemorrhage (SH), fresh blood (B), lysed blood (LB), thrombin (T) and kainate seizures (K).

The columns indicate the numbers of miRNAs that were detectable by RT-PCR; had a fold change >1.5; a fold change >1.5 and P<0.05; a fold change >1.5, P<0.05 and FDR <0.05.

^aRepresents miRNAs regulated in both brain and blood and had a fold change >2.