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. 2009 Oct 21;30(3):555–565. doi: 10.1038/jcbfm.2009.227

Figure 1.

Figure 1

Spontaneous neurotransmitter release recorded in CA1 pyramidal cells was glutamate-mediated and TTX-sensitive. (A) Spontaneous sEPSPs and currents (sEPSCs) recorded from a CA1 pyramidal neuron in current clamp (left) and from another neuron in voltage clamp (right), respectively. CNQX (10 μmol/L) and AP5 (50 μmol/L) completely and reversibly blocked sEPSPs/sEPSCs of all sizes in these neurons. The holding potentials for both neurons were −70 mV. (B) TTX (1 μmol/L) eliminated large-amplitude sEPSCs. (C) Plot of amplitude versus time of the sEPSCs before TTX application for a 30-min continuous recording. (D) Plot of amplitude versus time of the sEPSCs after TTX application for a 30-min continuous recording in the same cell as in panel C.