Figure 6.

CA3 activity was enhanced during transient H/H. (A) Voltage trace recorded from a CA3 neuron before, during, and after 2-min H/H challenge. No current (I=0) was injected into the cell. The black line represents the period of the H/H episode. Transient H/H caused minor depolarization and increase in the spontaneous firing frequency of the CA3 pyramidal cell. (B) Extended time-scale for the traces indicated by ‘1', ‘2', and ‘3' in panel A. (C) Statistical summary of the firing frequency observed before and during H/H. (D) Statistical summary of the incident of EPSPs observed before and during H/H in CA3 (n=8). (E) AP-V prevented the minor depolarization, high-frequency firing and the associated EPSPs in the CA3 neurons during transient H/H.