Table 1. Mean (n=5 baboons), standard deviations of the model parameters identified in the seven ROIs and regional autoradiographic densities obtained in human braina.
Parameters | Parameter estimates±standard deviations | ||||||
---|---|---|---|---|---|---|---|
Frontal Ctx | Parietal Ctx | Thalamus | Pons | Caudate | Putamen | Cerebellum | |
B′max (pmol/mL) | 199±26 | 141±27 | 182±24 | 145±38 | 194±26 | 194±30 | 66±13 |
k1 (min−1) | 0.367±0.071 | 0.341±0.050 | 0.404±0.071 | 0.402±0.097 | 0.424±0.077 | 0.487±0.110 | 0.470±0.102 |
k2 (min−1) | 0.495±0.051 | 0.474±0.037 | 0.448±0.032 | 0.522±0.075 | 0.513±0.052 | 0.546±0.068 | 0.588±0.050 |
kon/VR mL/(pmol min) | 0.006±0.0017 | 0.008±0.0027 | 0.005±0.0013 | 0.005±0.0010 | 0.006±0.0019 | 0.005±0.0015 | 0.006±0.0019 |
koff (min−1) | 0.038±0.012 | 0.045±0.011 | 0.032±0.008 | 0.025±0.010 | 0.036±0.013 | 0.032±0.011 | 0.041±0.008 |
k5 (min−1) | 0.011±0.009 | 0.011±0.008 | 0.010±0.010 | 0.023±0.024 | 0.016±0.013 | 0.008±0.007 | 0.011±0.009 |
k6 (min−1) | 0.026±0.025 | 0.034±0.043 | 0.044±0.057 | 0.057±0.060 | 0.060±0.058 | 0.033±0.030 | 0.024±0.022 |
KdVR (nmol/L) | 6.1±1.2 | 5.7±1.1 | 6.8±1.1 | 6.2±2.8 | 6.5±1.6 | 6.4±1.4 | 6.9±1.5 |
In vitro Bmax (humans) (pmol/mL)a | NA | NA | NA | 265 | 246 | 235 | 99 |
NA, not available.
From Saura et al (1996).