Table 2. Individual model parameters identified in the frontal cortex during the five PET experiments.

Parameters	Parameter estimates±standard errorsa					Mean
	Experiment 1	Experiment 2	Experiment 3	Experiment 4	Experiment 5	±s.d.
B′max (pmol/mL)	232±14	211±11	163.7±3.4	204.0±7.2	182.8±4.6	198.8±26.4
k1 (min−1)	0.298±0.013	0.459±0.024	0.348±0.005	0.307±0.015	0.423±0.010	0.367±0.071
k2 (min−1)	0.425±0.037	0.549±0.039	0.483±0.007	0.478±0.023	0.542±0.020	0.495±0.051
kon/VR mL/(pmol min)	0.0052±0.0005	0.0069±0.0009	0.0061±0.0002	0.0043±0.0005	0.0087±0.0006	0.0062±0.0017
koff (min−1)	0.029±0.004	0.056±0.007	0.033±0.001	0.027±0.003	0.044±0.005	0.038±0.012
k5 (min−1)	0.0128±0.0025	0.0043±0.0010	0.0131±0.0006	0.0007±0.0001	0.0227±0.0012	0.0107±0.0086
k6 (min−1)	0.053±0.011	0.0003±0.0001	0.036±0.001	0.0003±0.0002	0.043±0.002	0.026±0.024
KdVR (nmol/L)	5.6±1.3	8.1±2.1	5.3±0.4	6.3±1.5	5.07±0.93	6.1±1.2

^aStandard errors estimated from the covariance matrix.