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Deficiency of PAR4 reduced edema after I/R injury. Edema was assessed after 1 h MCAO and 23 h reperfusion in both wild-type (n=9) and PAR4−/−mice (n=10). Cerebral edema was determined by the percent increase of the ipsilateral/contralateral hemisphere area. (*P<0.05 is considered as significantly different compared with wild type; mean±s.e.m.).
