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. 2010 Jan 20;30(5):1044–1052. doi: 10.1038/jcbfm.2009.283

Figure 5.

Figure 5

Effect of PAR4 on the rolling and adhesion of platelets and leukocytes. (A) Video images of capturing platelets labeled with CFDASE or leukocytes labeled with Rhodamine 6G in the ischemic area 24 h after MCAO in both wild-type and PAR4−/− mice. Arrows indicate labeled platelets or leukocytes flowing through venules. Scale bar=40 μm. The rolling and adhesion of platelets (B and C) and leukocytes (D and A) in murine brain microvascular venules after 1 h MCAO and 23 h reperfusion were evaluated. Five animals were evaluated in each group. *P<0.05; **P<0.01 relative to the corresponding wild-type group values.