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Chemical structures of TM5007 (A) and TM5275 (B). Molecular weights for TM5007 and TM5275 are 560.02 and 543.97, respectively. On SDS-PAGE (C), PAI-1 formed a covalent complex with tPA, whereas no PAI-1/tPA complex formation was observed when PAI-1 was preincubated with TM5275.
