Table 4. Role of acute DWI lesion cut point (<>25 mL) in predicting excellent and poor outcome (patients without ICA occlusion).

	Univariate		Multivariate
Variable	OR (95% CI)	P value	OR (95% CI)	P value
Excellent outcome—placebo group (n=35)
DWI <25 mL	2.7 (0.5–15.3)	0.270
Excellent outcome—tPA (n=43)
DWI <25 mL	17.0 (3.1–92.4)	0.001	15.8 (2.03–99.8)	0.008
Infarct growth	0.99 (0.97–1.00)	0.132
Occlusion site	0.99 (0.81–1.19)	0.886
Tmax +2 secs vol	1.0 (0.99–1.00)	0.256
Tmax +12 secs vol	0.98 (0.96–1.00)	0.079	0.99 (0.98–1.02)	0.983
Reperfusion	1.0 (0.21–4.56)	1.0
Poor outcome—placebo group (n=35)
DWI >25 mL	1.3 (0.2–9.3)	0.772
Poor outcome—tPA (n=43)
DWI >25 mL	9.9 (1.8–54.4)	0.008	1.78 (0.19–16.5)	0.313
Infarct growth	1.02 (1.01–1.04)	0.017	1.03 (1.00–1.07)	0.040
Occlusion site	0.96 (0.74–1.24)	0.742
Tmax +2 secs vol	1.0 (0.99–1.00)	0.150
Tmax +12 secs vol	1.02 (1.00–1.03)	0.055	1.02 (0.99–1.05)	0.068
Reperfusion	0.26 (0.04–1.90)	0.184
tPA patients (n=43)
Variable	DWI <25 mL	DWI >25 mL	P value
Infarct growth	0 (0–12.1)	7.9 (0–93.1)	0.118
Occl site (M1)	7/22 (32%)	6/15 (40%)	0.609
Occl site (M2)	4/22 (18%)	2/15 (13%)	1.0
Occl site (nil)	11/22 (50%)	7/15 (47%)	0.842
Tmax +2 secs vol	122 (41–168)	156 (99–220)	0.178
Tmax +12 secs vol	8 (0–16)	49 (17–121)	0.002
Reperfusion	13/18 (72%)	8/13 (62%)	0.701

Abbreviations: CI, confidence interval; Occl, occlusion, lesion volumes are median and inter-quartile range in brackets.